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Researchers at the University of Cambridge and in the U.S. have created an embryo-like model from human stem cells to better understand post-implantation embryo development.

This 3D structure derived from pluripotent stem cells replicates some developmental processes that occur in early human embryos. With this model, researchers can now probe key questions of human post-implantation development, a critical window when approximately 60% of pregnancies fail to progress.

This new model may enable researchers to manipulate genes to understand their developmental roles in embryo development and offers a window into understanding causes of birth defects that previously could only be studied in animal models. While further optimization is needed, this is a significant step forward in understanding post-implantation embryo development.

Reference: https://doi.org/10.1038/s41586-023-06368-y

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